Liu, Xiaoyu; He, Kun; Gao, Na; Jiang, Peiyun; Lin, Jun; Jin, Yi published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A radical-mediated multicomponent cascade reaction for the synthesis of azide-biindole derivatives》.Formula: C8H6FN The article contains the following contents:
A radical-mediated, one-pot, multicomponent cascade reaction was developed for the synthesis of azide-biindole derivatives Mechanistic studies demonstrated that the nitrogen-centered free radical were formed by the reaction of heterocyclic N-H with CuII and PIFA and initiated the cascade reaction with indole to obtain the biindole intermediate. The obtained biindole intermediate then reacted with sodium azide in the presence of CuII catalyst and PIFA which then resulted in final products. This methodol. was useful for constructing other azido heterocycles. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Formula: C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles