Recommanded Product: 120-72-9In 2019 ,《Indole: A privileged scaffold for the design of anti-cancer agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Wan, Yichao; Li, Yuanhua; Yan, Chunxing; Yan, Mi; Tang, Zilong. The article conveys some information:
A review. In general, heterocyclic compounds are a significant source of pharmacol. active compounds Among them, the indole scaffold widely distributes in natural products and bioactive mols. including anti-cancer agents. In view of its unique physic-chem. and biol. properties, it has been used as a privileged scaffold in the anti-cancer agents design. So far, many natural and synthetic indole derivatives have been discovered as promising anti-cancer agents used in clinic or clin. evaluations, suggesting its prominent place in anti-cancer drugs development. This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim) inhibitors, histone deacetylase (HDAC) inhibitors, silent mating type information regulation 2 homolog (SIRT) inhibitors and tubulin inhibitors, and made an insight into the corresponding structure-activity relationships (SARs). We hope the review could give a guide to develop new anti-cancer agents with greater potency against drug-sensitive and drug-resistant cancers in the future. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9)
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 120-72-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles