In 2019,Angewandte Chemie, International Edition included an article by Ma, Chun; Jiang, Fei; Sheng, Feng-Tao; Jiao, Yinchun; Mei, Guang-Jian; Shi, Feng. Application of 120-72-9. The article was titled 《Design and Catalytic Asymmetric Construction of Axially Chiral 3,3′-Bisindole Skeletons》. The information in the text is summarized as follows:
The first catalytic asym. construction of 3,3′-bisindole skeletons bearing both axial and central chirality has been established by organocatalytic asym. addition reactions of 2-substituted 3,3′-bisindoles with 3-indolylmethanols (up to 98 % yield, all >95:5 d.r., >99 % ee). This reaction also represents the first highly enantioselective construction of axially chiral 3,3′-bisindole skeletons, and utilizes the strategy of introducing a bulky group to the ortho-position of prochiral 3,3′-bisindoles. This reaction not only provides a good example for simultaneously controlling axial and central chirality in one operation, but also serves as a new strategy for catalytic enantioselective construction of axially chiral 3,3′-bisindole backbones from prochiral substrates. After reading the article, we found that the author used 1H-Indole(cas: 120-72-9Application of 120-72-9)
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 120-72-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles