In 2022,Zhang, Shang-Shi; Liu, Yan-Zhi; Zheng, Yi-Chuan; Xie, Hui; Chen, Shao-Yong; Song, Jia-Lin; Shu, Bing published an article in Advanced Synthesis & Catalysis. The title of the article was 《Rhodium(III)-Catalyzed Regioselective C-H Allylation and Prenylation of Indoles at C4-Position》.SDS of cas: 399-52-0 The author mentioned the following in the article:
Herein, Rh(III)-catalyzed C4-selective C-H allylation and prenylation of indoles, e.g., I (R = H), by using a weak carbonyl coordination directing group have been reported. By employing 5-methylene-1,3-dioxan-2-ones, 4-vinyl-1,3-dioxolan-2-ones and 2-methyl-2,3-butadiene as scalable cross-coupling partners, these divergent synthesis protocols proceed smoothly under redox-neutral reaction conditions, delivering various allylated and prenylated indoles, e.g., I [R = CH2C(=CH2)CH2OH, CH2CH=CHCH2OH], in moderate to satisfactory yields. This transformation exhibits high functional-groups compatibility and broad substrate scope. A scale-up experiment and mechanistic studies were also accomplished. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles