《Dynamics of transcription-translation coordination tune bacterial indole signaling》 was published in Nature Chemical Biology in 2020. These research results belong to Wang, Tianmin; Zheng, Xiang; Ji, Haonan; Wang, Ting-Liang; Xing, Xin-Hui; Zhang, Chong. Recommanded Product: 120-72-9 The article mentions the following:
Indole signaling is an important cross-species communication pathway in the mammalian gut. In bacteria, upon induction by tryptophan, the mol. sensor (tnaC) controls indole biosynthesis by precisely coordinating dynamics of the corresponding macromol. machineries during its transcription and translation. The authors’ understanding of this regulatory program is still limited owing to its rapid dynamic nature. To address this shortcoming, the authors adopted a massively parallel profiling method to quantify the responses of 1450 synthetic tnaC variants in the presence of three concentrations of tryptophan in living bacterial cells. The resultant dataset enabled the authors to comprehensively probe the key intermediate states of macromol. machineries during the transcription and translation of tnaC. The authors also used modeling to provide a systems-level understanding of how these critical states collectively shape the output of this regulatory program quant. A similar methodol. will likely apply to other poorly understood dynamics-dependent cis-regulatory elements. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9)
1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 120-72-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles