Galvan, Alicia; Calleja, Jonas; Gonzalez-Perez, Adan B.; Alvarez, Rosana; de Lera, Angel R.; Fananas, Francisco J.; Rodriguez, Felix published an article in 2015, the title of the article was Stereoselective [3+2] Carbocyclization of Indole-Derived Imines and Electron-Rich Alkenes: A Divergent Synthesis of Cyclopenta[b]indole or Tetrahydroquinoline Derivatives.Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:
An unprecedented stereoselective [3+2] carbocyclization reaction of indole-2-carboxaldehydes, anilines, and electron-rich alkenes to obtain cyclopenta[b]indoles is disclosed. This pathway is different from the well-established Povarov reaction: the formal [4+2] cycloaddition involving the same components, which affords tetrahydroquinolines. Moreover, by simply changing the Bronsted acid catalyst, this multicomponent coupling process could be divergently directed towards the conventional Povarov pathway to produce tetrahydroquinolines or to the new pathway (anti-Povarov) to generate cyclopenta[b]indoles. Supported by computational studies, a stepwise Mannich/Friedel-Crafts cascade is proposed for the new anti-Povarov reaction, whereas a concerted [4+2] cycloaddition mechanism is proposed for the Povarov reaction. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde
The Article related to cyclopentaindole derivative stereoselective preparation, tetrahydroquinoline derivative stereoselective preparation, indolecarboxaldehyde arylamine dihydrofuran stereoselective carbocyclization, acid catalysis, divergent synthesis, heterocycles, indoles, synthetic methods and other aspects.Name: 1,5-Dimethyl-1H-indole-2-carbaldehyde
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles