On May 20, 2010, Shipps, Gerald W., Jr.; Cheng, Cliff C.; Huang, Xiaohua; Achab, Abdelghani Abe; Orth, Peter; Voigt, Johannes H.; Soucy, Kyle Ann published a patent.Reference of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of aryldihydrotriazolopyrimidinone derivatives and analogs for use as fatty acid binding protein (FABP) inhibitors. And the patent contained the following:
Title compounds I [G = CR6; X = S, O, NH, etc.; or when X is CR7 or N, then X and G or X and ring Y together form a cycloalkyl or heterocyclyl ring containing 1 to 3 heteroatoms selected from N, O, or S; ring Y = (un)substituted aryl, heteroaryl, heterocyclyl, or cycloalkyl; Z = H, (un)substituted alkyl, cycloalkyl, aryl, etc.; R1 = H, alkyl, haloalkyl, haloalkoxy, etc.; each R2 independently = halo, CN, (un)substituted alkyl, etc.; R6 = absent, H, halo, (un)substituted alkyl, etc.; R7 = H, OH, (un)substituted alkoxy, or alkyl; R9 = H, halo, (un)substituted alkyl, etc.; R10 = H, halo, C(O)OH, C(O)NH2, etc.; m = 1 or 2; n = 0 to 4; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as fatty acid binding protein (FABP) inhibitors. Thus, e.g., II was prepared by cyclization of 3-phenyl-1H-1,2,4-triazol-5-amine with Et 4-chloro-3-oxobutanoate followed by esterification with 3-chloro-2-methylphenol. I were evaluated in temperature dependence fluorescence (TdF) assays for FABP4, e.g., II demonstrated an Kd value of >0.001 to 0.5 μM. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Reference of 6-Chloro-2,3-dihydro-1H-indole
The Article related to triazolopyrimidinone aryldihydro derivative preparation fatty acid binding protein inhibitor, aryldihydrotriazolopyrimidinone analog preparation fatty acid binding protein fabp inhibitor and other aspects.Reference of 6-Chloro-2,3-dihydro-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles