On September 10, 2010, Kaizawa, Hiroyuki; Sugita, Mari; Azami, Hidenori; Seo, Ryushi; Nomura, Takaho; Yamamoto, Satoshi; Yamamoto, Hirofumi; Tsuchiya, Kazuyuki; Kubota, Hideki; Kamijo, Kazunori published a patent.HPLC of Formula: 52537-00-5 The title of the patent was Preparation of quinoxaline compounds as PDE9 inhibitors. And the patent contained the following:
Title compounds I [one A1 and A2 is N, the other is CR6 or N; one of R1 and R2 is H, halo, (un)substituted alkyl, etc., the other is -CONRaRb; R3 = (un)substituted alkyl, cycloalkyl, cycloalkenyl, etc.; R4, R5 = H or alkyl; R6 = H or alkyl; Ra, Rb = H, (un)substituted alkyl, cycloalkyl, etc.] or salts thereof were prepared For example, reaction of 3-chloro-2-hydrazino-7-methylquinoxaline-6-carboxylic acid Me ester with 3-chloro-4-hydroxybenzaldehyde in the presence of Cu(OAc)2 followed by hydrolysis and EDCI-mediated amidation with 1-pyridin-4-yl-1,2,3,4-tetrahydroisoquinoline afforded compound II. In PDE9 inhibition assays, IC50 of II was 2.3 nM. Compounds I are claimed useful for the treatment of urine collection disorder, urination disorder, etc. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5
The Article related to quinoxaline preparation pde9 inhibitor, urine collection disorder treatment quinoxaline preparation pde9 inhibition, urination disorder treatment quinoxaline preparation pde9 inhibition and other aspects.HPLC of Formula: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles