On February 6, 1996, Hashimoto, Rie; Okada, Hideo; Mochizuki, Atsuya; Ooi, Hideo; Endo, Mamoru; Miki, Wataru; Konya, Kazumi published a patent.Computed Properties of 52537-00-5 The title of the patent was Preparation of 5,6-dichloro-1-methylgramine and antifouling agents against adhering aquatic organisms. And the patent contained the following:
The title compound (I) is prepared An antifouling agent against adhering aquatic organisms contains at least one compound selected from 5,6-dichlorogramine, 5-chloro-2-methylgramine, 5-bromo-2-methylgramine, 1,2-dimethyl-6-bromogramine, and I as the active ingredient. This antifouling agent prevents aquatic organisms such as sea weeds, barnacles, Mytilus edulis, etc. adhering and damaging a bottom of a ship, a fishing net, a buoy, aqueous structures such as facilities attached to a dam and bay, and water inlet channels for cooling water of a condenser for a power plant or an heat exchanger in petrochem. industry. Thus, 1.9 g 5,6-dichloroindole was dissolved in DMF, treated with NaH at 5°, stirred at 5° for 30 min, treated dropwise with 1.5 g MeI, and stirred at room temperature for 3 h to give 2.2. g crude 5,6-dichloro-1-methylindole, which was added to a solution of 1.3 mL 40% dimethylamine, 0.9 mL 35% formalin, and 1.7 mL AcOH, and stirred overnight to give 61.5% I. I (0.0025 mg) was dissolved in 0.1 mL MeOH, coated on a round petri dish (diameter 4 cm), and dried. Filtered sea water (5 mL) and 10 barnacle larvae were added to the treated petri dish and left in the dark at 23° for 24 h to show that no larvae adhered to the petri dish. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Computed Properties of 52537-00-5
The Article related to chloromethylgramine preparation antifouling agent, aquatic organism antifouling agent, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles