Kerns, Jeffrey K.’s team published research in ACS Medicinal Chemistry Letters in 9 | CAS: 860624-90-4

ACS Medicinal Chemistry Letters published new progress about 860624-90-4. 860624-90-4 belongs to indole-building-block, auxiliary class Indole,Bromide,Carboxylic acid,Indole, name is 5-Bromo-1H-indole-7-carboxylic acid, and the molecular formula is C9H6BrNO2, Formula: C9H6BrNO2.

Kerns, Jeffrey K. published the artcile3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent, Formula: C9H6BrNO2, the publication is ACS Medicinal Chemistry Letters (2018), 9(12), 1164-1169, database is CAplus and MEDLINE.

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein the authors report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so, the authors focused attention on potency, ligand efficiency (LE), and physicochem. properties and have identified compounds I and II as having robust in vivo activity.

ACS Medicinal Chemistry Letters published new progress about 860624-90-4. 860624-90-4 belongs to indole-building-block, auxiliary class Indole,Bromide,Carboxylic acid,Indole, name is 5-Bromo-1H-indole-7-carboxylic acid, and the molecular formula is C9H6BrNO2, Formula: C9H6BrNO2.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles