Effect of hydrogen bonding and solvation of 5-substituted indole carboxldehydes in methanol-benzene was written by Heda, L. C.;Sharma, Rashmi;Chaudhari, Pramod B.. And the article was included in Research Journal of Chemical Sciences in 2011.Name: 5-Chloroindole-3-carboxaldehyde This article mentions the following:
Effect of hydrogen bonding of 5-substituted indole carboxaldehyde was studied by viscometric measurement. The viscosity of the system increases with the increase in concentration The Trend Change Point (TCP) values were determined by intersection of two straight lines, which are dependent on the composition of solvent mixtures The study confirms that the nature of synthesized compounds forms clusters in methanol-benzene mixture The viscometric data were analyzed in terms of Einstein, Vand, Moulik and Jones-Dole equations. These known equations were successfully applied to explain the results of viscosity measurements and the viscometric parameters show that the behavior of compound changes in alc.-benzene. The formation of cluster depends on the methanol concentration The observed methanol concentration effect on the formation of clusters interferences in formation of hydrogen bonding of methanol with mol. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Name: 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 5-Chloroindole-3-carboxaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles