One-pot synthesis of pyrrolidones from levulinic acid and amines/nitroarenes/nitriles over the Ir-PVP catalyst was written by Chaudhari, Chandan;Shiraishi, Masaya;Nishida, Yoshihide;Sato, Katsutoshi;Nagaoka, Katsutoshi. And the article was included in Green Chemistry in 2020.Application In Synthesis of 2-Phenylisoindolin-1-one This article mentions the following:
The synthesis of pyrrolidones I (R = C6H5, CH2C6H5, 4-FC6H4, etc.) via reductive amination of levulinic acid with aniline was examined over polypyrrolidone-stabilized metal nanoparticle catalysts. Among them, Ir metal was the most effective and applicable for the reductive amination of levulinic acid with nitroarenes R1NO2 (R1 = C6H5, 4-CH3OC6H4, 4-CH3C6H4, 4-ClC6H4, 4-FC6H4)/nitriles R2CN (R2 = C6H5, 4-CH3OC6H4, 4-CH3C6H4, 4-ClC6H4, 4-CF3C6H4). Importantly, this catalyst was used for the one-pot synthesis of the anti-inflammatory drug indoprofen from 2-formylbenzoic acid and 2-(4-nitrophenyl)propanoic acid. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Application In Synthesis of 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles