Novel cyclopropapyrroloindole derivative (AT-3510) bearing methoxycarbonyl and trifluoromethyl groups was written by Fukuda, Yasumichi;Furuta, Hirosuke;Kusama, Yoshie;Ebisu, Hiroyuki;Oomori, Yasuo;Terashima, Shiro. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 210345-56-5 This article mentions the following:
The seco-Cl 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) derivatives dl- and/or (S)-I [Ar = Q, Q1, Q2, Q3, R = 4,5,6-(MeO)3, 5,6,7-(MeO)3, 5-MeO, etc., X = NH, O, CH, Y = CH, N] carrying various acyl moieties at the N6-position were synthesized along with their prodrugs (S)-II, and their antitumor activity was evaluated. Among these derivatives, AT-3510 [(S)-II (Ar = Q1, R = 7-MeO, X = O)], the novel prodrug MCTFCPI derivative carrying a 5-(7-methoxybenzofuran-2-ylcarbonyl)aminoindole-2-carbonyl group at the N6-position, was found to exhibit more excellent antitumor activity against human tumor xenografts than the clin. trial candidates carzelesin and KW-2189 (III) and cisplatin. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5HPLC of Formula: 210345-56-5).
Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 210345-56-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles