Synthesis of 3-(indolyl)propanoic acid and its derivatives was written by Yu, Liangmin;Li, Xia;Yan, Xuefeng;Yu, Liangzhi. And the article was included in Zhongguo Haiyang Daxue Xuebao, Ziran Kexueban in 2009.Synthetic Route of C11H11NO2 This article mentions the following:
A method for the synthesis of the title compounds [i.e., 1H-indole-1-propanoic acid derivatives] is reported here. Reaction of indole derivatives with 3,3′-dithiobis[propanoic acid] di-Me ester gave 1H-indole-1-propanoic acid Me ester derivatives Saponification/hydrolysis of these intermediates and acidification delivered the target compounds (49.5%, 50.8%, 35.1% yield). Product structures were determined by IR and NMR. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Synthetic Route of C11H11NO2).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C11H11NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles