Facile Synthesis of Carbazoles via a Tandem Iodocyclization with 1,2-Alkyl Migration and Aromatization was written by Wang, Jia;Zhu, Hai-Tao;Qiu, Yi-Feng;Niu, Yuan;Chen, Si;Li, Ying-Xiu;Liu, Xue-Yuan;Liang, Yong-Min. And the article was included in Organic Letters in 2015.Recommanded Product: 827-01-0 This article mentions the following:
A strategy for the synthesis of iodocarbazoles through a tandem iodocyclization with migration and aromatization is presented. E.g., reaction of 1-(1-methyl-1H-indol-3-yl)-4-phenylbut-3-yn-1-ol (I) with 2.0 equiv of ICl at room temperature gave 89% iodocarbazole derivative (II). This sequential cascade process is concisely conducted at room temperature and in a short time. Moreover, the obtained halides can be further applied to palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Recommanded Product: 827-01-0).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 827-01-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles