Synthesis of phthalimidines from aromatic dicarbonyl compounds was written by Yamamoto, Iwao;Yanagi, Shoichi;Mamba, Akio;Gotoh, Haruo. And the article was included in Journal of Organic Chemistry in 1974.HPLC of Formula: 5388-42-1 This article mentions the following:
Addnl. data considered in abstracting and indexing are available from a source cited in the original document. The reaction between o-benzoylbenzaldehyde (I) and aromatic isocyanates RNCO (R = Ph, m-tolyl, α- and β-naphthyl) afforded 2,3-disubstituted phthalimidines II in good yield, which would be formed via o-benzoylbenzylideneaniline intermediate followed by migration of Ph group. The same product II (R = Ph) was obtained by the reaction using I and aniline. On the other hand, no reaction was observed between o-carbethoxybenzaldehyde (III) and PhNCO, but the reaction of III with aniline gave o-carbethoxybenzylideneaniline and 3-anilino-2-phenylphthalimidine in 83% and 7% yields, resp. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1HPLC of Formula: 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 5388-42-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles