Synthesis and antioxidant activity of 3-[4-(2,5-dimethylamino-1H-pyrrol-1-yl-phenyl)][1,3,4]-oxadiazino[6,5-b]substituted indole was written by Padma, Bairy;Gadea, Sammaiah. And the article was included in International Journal of Research in Pharmacy and Chemistry in 2020.Reference of 112656-95-8 This article mentions the following:
Fifteen new 3-[4-(2,5-di-Me amino-1H pyrrol-1-yl-phenyl)][1,3,4]-oxadiazino [6,5-b] substituted indoles I (R = 6-Cl, 8-Br, 6-F, etc.) have been synthesized. The chem. structures of the products I were confirmed by 1HNMR, IR and mass spectral data. The compounds I were screened for antioxidant activity by standard DPPH assay method. IC50 values of these compounds I were determined Compounds I (R = 8-F, 8-C(O)2H, 8-C(O)2Et) potent antioxidant and remaining compounds showed significant antioxidant activity. Ascorbic acid was taken as standard drug. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Reference of 112656-95-8).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Reference of 112656-95-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles