Urea derivative catalyzed enantioselective aldol reaction of isatins with ketones was written by Wang, Li Ming;Zhao, Mei Jun;Chen, Zhe;Mu, Hong Wen;Jin, Ying. And the article was included in Chirality in 2018.Formula: C8H3F2NO2 This article mentions the following:
An efficient method was developed for the synthesis of 3-alkyl-3-hydroxyindolin-2-ones I (R1 = H, 5-Me, 7-F, etc.; R2 = Me, Ph, 4-ClC6H4) via chiral urea-catalyzed asym. aldol reaction of isatins with ketones R2C(O)Me. The resulting products I were obtained in good yields (70%-94%) with high enantioselectivities (up to 87% ee). In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Formula: C8H3F2NO2).
5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Formula: C8H3F2NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles