Synthesis of novel pyridobenzimidazoles bonded to indole or benzo[b]thiophene structures was written by Kamila, Sukanta;Ankati, Haribabu;Mendoza, Kimberly;Biehl, Edward R.. And the article was included in Open Organic Chemistry Journal in 2011.Recommanded Product: 5-Chloroindole-3-carboxaldehyde This article mentions the following:
Pyridobenzimidazoles I (R1 = R2 = R3 = H, X = NH, Y = CH; R1 = MeO, R2 = R3 = H, X = NH, Y = N; R1 = R, R2 = R3 = H, X = S, Y = CH; etc.) were synthesized in very good to excellent yields (81-96 %) by the condensation of substituted N-phenyl-o-phenylenediamines with indole/benzo[b]thiophene-3-aldehydes 5a-t in methoxyethanol under reflux conditions. The diamines were prepared by first treating 2-chloro-3-nitropyridine with suitably substituted anilines, then reducing the resulting 3-nitro-N-phenylpyridin-2-amines with tin(II)chloride using microwave heating in each case. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Recommanded Product: 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 5-Chloroindole-3-carboxaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles