Palladium oxidative addition complex-enabled synthesis of amino-substituted indolyl-4(3H)-quinazolinones and their antitumor activity evaluation was written by Jiang, Zhi;Zhao, Dan-Dan;Hu, Yu-Tao;Rao, Yong;Guo, Shi-Yao;Xu, Yao-Hao;Li, Qingjiang;Huang, Zhi-Shu. And the article was included in Organic & Biomolecular Chemistry in 2022.Computed Properties of C9H6BrNO2 This article mentions the following:
A palladium-mediated amination of halogen-containing indolyl-4(3H)-quinazolinones such as I (R = Br) with a variety of primary and secondary amines, e.g., morpholine via the corresponding palladium oxidative addition complexes was reported. The protocol allows the facile synthesis of indolyl-4(3H)-quinazolinone derivatives with amino groups at all the positions of the benzene ring such as I (R = 4-morpholinyl) in moderate to good yields with mild reaction conditions and good functional group tolerance. Furthermore, the antitumor activity of these products was evaluated. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Computed Properties of C9H6BrNO2).
4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C9H6BrNO2
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles