N2-Selective 闁?Thioalkylation of Benzotriazoles with Alkenes was written by Zhu, Li-Li;Tian, Lifang;Sun, Kunhui;Li, Yiwen;Liu, Guanglu;Cai, Bin;Zhang, Hui;Wang, Yahui. And the article was included in Journal of Organic Chemistry in 2022.Application of 14204-27-4 This article mentions the following:
Herein, N2-selective 闁?thioalkylation of benzotriazoles with unactivated alkenes and styrenes is reported. The N2-selective 闁?thioalkylation of benzotriazoles is highly stereospecific and works under simple and mild conditions, exhibiting excellent functional group tolerance. The high N2-selectivity is a consequence of the combination of hydrogen bonding and Lewis acid/base activation, which reverses the N2-position to be favored for alkylation. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Application of 14204-27-4).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application of 14204-27-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles