Total Synthesis of (-)-Aspergilazine A was written by Boyd, Emily M.;Sperry, Jonathan. And the article was included in Organic Letters in 2014.Quality Control of (S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid This article mentions the following:
The total synthesis of (-)-aspergilazine A (I), an alkaloid possessing a rare N1′ to C6 bisindole bond, is described. A palladium-catalyzed N-arylation was used to selectively install the N1′-C6 bond in the presence of three other possible arylation sites. The ligand XPhos displayed a unique capability to efficiently carry out the N-arylation while simultaneously suppressing epimerization of the sensitive C9 stereocenters. This total synthesis has confirmed that aspergilazine A is a dimer of brevianamide F. In the experiment, the researchers used many compounds, for example, (S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid (cas: 52448-17-6Quality Control of (S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid).
(S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid (cas: 52448-17-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Quality Control of (S)-2-Amino-3-(6-bromo-1H-indol-3-yl)propanoic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles