Direct Difluoromethylenation of Carbonyl Compounds Using TMSCF3: The Right Conditions was written by Prakash, Surya G.;Krishnamoorthy, Sankarganesh;Kothandaraman, Jotheeswari;Saldana, Jacqueline. And the article was included in European Journal of Organic Chemistry in 2016.Recommanded Product: 27421-51-8 This article mentions the following:
Using readily available, inexpensive trifluoromethyltrimethylsilane (TMSCF3), LiI and PPh3, deoxygenative difluoromethylenation of carbonyl compounds is reported. The Li+ is proposed to prevent the unproductive exhaustion of TMSCF3 by keeping the soluble free fluoride concentration in the reaction medium under control. Also, solvent combination strategy to increase the reactivity and thereby reducing the reaction temperature and time is disclosed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8Recommanded Product: 27421-51-8).
1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 27421-51-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles