Chemistry, like all the natural sciences, Formula: C10H12FN5O4, begins with the direct observation of nature¡ª in this case, of matter.21679-14-1, Name is 9-¦Â-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine, SMILES is [C@@H]3([N]1C2=C(N=C1)C(=NC(=N2)F)N)O[C@H](CO)[C@H]([C@@H]3O)O, belongs to indole-building-block compound. In a document, author is Kitano, Hiroyuki, introduce the new discover.
Annulative pi-extension of indoles and pyrroles with diiodobiaryls by Pd catalysis: rapid synthesis of nitrogen-containing polycyclic aromatic compounds
A palladium-catalyzed one-step annulative -extension (APEX) reaction of indoles and pyrroles that allows rapid access to nitrogen-containing polycyclic aromatic compounds is described. In the presence of palladium pivalate and silver carbonate, diverse indoles or pyrroles coupled with diiodobiaryls in a double direct C-H arylation manner to be transformed into the corresponding -extended compounds in a single step. The newly developed catalytic system enables the use of various pyrroles and indoles as templates with a series of diiodobiaryls to provide structurally complicated and largely -extended nitrogen-containing polycyclic aromatic compounds that are otherwise difficult to synthesize.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 21679-14-1. Formula: C10H12FN5O4.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles