In an article, author is Bresnahan, Caitlin G., once mentioned the application of 52488-36-5, Name is 4-Bromo-1H-indole, molecular formula is C8H6BrN, molecular weight is 196.04, MDL number is MFCD00671502, category is indole-building-block. Now introduce a scientific discovery about this category, Computed Properties of C8H6BrN.
Mechanistic Perspectives in the Regioselective Indole Addition to Unsymmetrical Silyloxyallyl Cations
Our investigations on the reaction mechanism to account for regioselectivity on the addition of indoles to unsymmetrical silyloxyallyl cations are reported. Using both experimental and computational methods, we confirmed the significance of steric effects from the silyl ether group toward directing the inward approach of indoles, leading to nucleophilic attack at the less substituted electrophilic alpha’-carbon. The role of residual water toward accelerating the rate of reaction is established through stabilization of the participating silyloxyallyl cation.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 52488-36-5, Computed Properties of C8H6BrN.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles