387-43-9, 4-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 10-Synthesis of tert-butyl 4-fluoro-1H-indole-1-carboxylate To a solution of 4-fluoro-1H-indole (5 g, 0.11 mol) and DMAP (150 mg, 3percent Wt) in THF (50 mL) was added (Boc)2O (8.5 g, 0.04 mol) dropwise. The mixture was stirred at room temperature for 2 hours. The organic solvent was removed in vacuo, and the resulting residue was purified using column chromatography (pure petroleum ether) to provide tert-butyl 4-fluoro-1H-indole-1-carboxylate (8.3 g, yield: 96percent). 1H-NMR (CDCl3, 400 MHz) delta 7.92 (d, J=8.4 Hz, 1H), 7.55 (d, J=3.6 Hz, 1H), 7.23 (m, 1H), 6.90 (m, 1H), 6.66 (d, J=3.6 Hz, 1H), 1.67 (s, 9H). MS (M+H)+: 236.
387-43-9, The synthetic route of 387-43-9 has been constantly updated, and we look forward to future research findings.
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles