Electric Literature of 3189-13-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3189-13-7, Name is 6-Methoxyindole,introducing its new discovery.
“Chemical Equation Presented” The first example of central metal controlled reversal of enantioselectivity in asymmetric Friedel-Crafts alkylation of indoles andbetagamma-unsaturated alpha-ketoesters has been developed. Using the same chiral starting material derived N,N’-dioxides 1a and 1b as ligands, various indole esters 4 were obtained in good to excellent yields and enantioselectivities. The reaction also featured mild reaction conditions and remarkably low catalyst loading (down to 0.01 mol %).
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles