With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885520-70-7,4-Bromo-6-fluoro-1H-indole,as a common compound, the synthetic route is as follows.
885520-70-7, To a solution of 4-bromo-6-fluoro-indole (2 g, 9.38 mmol) in anhydrous tetrahydrofuran (30 mL) cooled in an ice bath was added sodium hydride (0.452 g, 11.3 mmol, 60percent in mineral oil). The reaction mixture was stirred under nitrogen for 10 min before benzenesulfonyl chloride (1.44 mL, 11.3 mmol) was added. The black solution was allowed to warm to room temperature over 4 h. TLC and LCMS indicated completion of the reaction. Saturated aqueous ammonium chloride solution was added slowly, and the resulting solution was extracted with ethyl acetate (2*). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude solid was triturated with ethanol. The resulting beige solid was collected by filtration to give 4-bromo-6-fluoro-1-(phenylsulfonyl)-1H-indole (2.6 g, 79percent yield).
The synthetic route of 885520-70-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PMV Pharmaceuticals, Inc.; Vu, Binh; Dominique, Romyr; Li, Hongju; (222 pag.)US2017/240525; (2017); A1;,
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