An article Benzyl C-O and C-N Bond Construction via C-C Bond Dissociation of Oxime Ester under Visible Light Irradiation WOS:000485342000001 published article about PROPARGYLIC SUBSTITUTION-REACTIONS; METAL-FREE; CATALYZED MONOALKYLATION; EFFICIENT CATALYSTS; ACYL OXIMES; AMINATION; ACTIVATION; ALCOHOLS; ACID; CHEMOSELECTIVITY in [Fan, Xiuwei; Lei, Tao; Liu, Zan; Yang, Xiu-Long; Cheng, Yuan-Yuan; Liang, Ge; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China; [Fan, Xiuwei; Lei, Tao; Liu, Zan; Yang, Xiu-Long; Cheng, Yuan-Yuan; Liang, Ge; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China in 2020.0, Cited 49.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Category: indole-building-block
A photoredox benzyl activation was developed via formidable C(sp(3))-C(sp(3)) bond dissociation of 1-aryl acetone oxime esters, which were easily prepared from benzyl ketones. Further coupling with O- and N- nucleophiles successfully forged important benzyl ether and amines derivatives in one pot. In this process, different substitutions on oxime esters were found compatible and various primary and secondary alcohols and amines, as well as amides showed good performance as nucleophiles. Mechanistic studies by control experiments, electrochemical measurements and in-situ NMR spectra proposed a N-O bond interruption/C-C bond fragmentation/oxidation sequence to provide the key cation intermediate for the next electrophilic S-N process. The features of mild condition, short reaction time and broad substrate scope made this new strategy much promising in the transformation of benzyl compounds, which might be valuable in last-stage functionalizations.
About Benzyl Alcohol, If you have any questions, you can contact Fan, XW; Lei, T; Liu, Z; Yang, XL; Cheng, YY; Liang, G; Chen, B; Tung, CH; Wu, LZ or concate me.. Category: indole-building-block
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles