Recently I am researching about PHARMACOKINETICS; ANESTHESIA; SAFETY, Saw an article supported by the Key Research AMP; Development Projects of the Department of Science AMP; Technology of Sichuan Province [2019YFS0093]. HPLC of Formula: C7H8O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clinically) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clinical benefits of propofol. The experimental results showed the potential of such compounds as water-soluble prodrugs of propofol.
HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles