244-69-9, 5H-Pyrido[4,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A solution of 4 mmol carboline (12 or 14) and 4.4 mmol of NaH in DMF was stirred at room temperature for 30 min. After addition of 4.4 mmol of corresponding alkyl halide the solution was stirred for another 4-16 h. The conversion was monitored by TLC and GC/MS. When no further reaction was observed the solution was poured into iced water extracted with dichloromethane and purified by column chromatography and was subsequently converted into its HCl salt in 2-propanol with ethereal HCl., 244-69-9
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Reference£º
Article; Otto, Robert; Penzis, Robert; Gaube, Friedemann; Winckler, Thomas; Appenroth, Dorothea; Fleck, Christian; Traenkle, Christian; Lehmann, Jochen; Enzensperger, Christoph; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 63 – 70;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles