Authors Pedrood, K; Sherafati, M; Mohammadi-Khanaposhtani, M; Asgari, MS; Hosseini, S; Rastegar, H; Larijani, B; Mahdavi, M; Taslimi, P; Erden, Y; Gunay, S; Gulcin, I in ELSEVIER published article about in [Pedrood, Keyvan; Sherafati, Maedeh; Larijani, Bagher; Mahdavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran; [Mohammadi-Khanaposhtani, Maryam] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran; [Asgari, Mohammad Sadegh] Iran Univ Sci & Technol, Dept Chem, Tehran, Iran; [Hosseini, Samanesadat] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran; [Rastegar, Hossein] MOHE, Cosmet Prod Res Ctr, Iranian Food & Drug Adm, Tehran, Iran; [Taslimi, Parham] Bartin Univ, Fac Sci, Dept Biotechnol, TR-74100 Bartin, Turkey; [Erden, Yavuz; Gunay, Sevilay] Bartin Univ, Fac Sci, Dept Mol Biol & Genet, TR-74100 Bartin, Turkey; [Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey in 2021, Cited 100. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against metabolic enzymes including alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, human carbonic anhydrase I, and II. These compounds exhibited high inhibitory activities in comparison to used standard inhibitors with K-i values in the range of 19.28-135.88 nM for alpha-glycosidase (K-i value for standard inhibitor = 187.71 nM), 0.68-23.01 nM for acetylcholinesterase (K-i value for standard inhibitor = 53.31 nM), 1.01-29.56 nM for butyrylcholinesterase (K-i value for standard inhibitor = 58.16 nM), 10.25-126.05 nM for human carbonic anhydrase I (K-i value for standard inhibitor = 248.18 nM), and 13.46-178.35 nM for human carbonic anhydrase II (K-i value for standard inhibitor = 323.72). Furthermore, the most potent compounds against each enzyme were selected in order to evaluate interaction modes of these compounds in the active site of the target enzyme. Cytotoxicity assay of the title compounds 7a-n against cancer cell lines MCF-7 and LNCaP demonstrated that these compounds do not show significant cytotoxic effects. (C) 2020 Published by Elsevier B.V.
SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Pedrood, K; Sherafati, M; Mohammadi-Khanaposhtani, M; Asgari, MS; Hosseini, S; Rastegar, H; Larijani, B; Mahdavi, M; Taslimi, P; Erden, Y; Gunay, S; Gulcin, I or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles