An article Strain-Induced Nucleophilic Ring Opening of Donor-Acceptor Cyclopropenes for Synthesis of Monosubstituted Succinic Acid Derivatives WOS:000592483300001 published article about CATALYZED CYCLOISOMERIZATION; STEREOSELECTIVE-SYNTHESIS; NORDITERPENOID ALKALOIDS; OXIDATION-STATE; CYCLIZATION; ESTERS in [Marichev, Kostiantyn O.; Wang, Kan; Greco, Nicole; Dong, Kuiyong; Doyle, Michael P.] Univ Texas San Antonio, Dept Chem, One UTSA Circle, San Antonio, TX 78249 USA; [Chen, Jinzhou; Lei, Jinping] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China in 2021.0, Cited 54.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Application In Synthesis of Benzyl Alcohol
1,2,3-Trisubstituted donor-acceptor cyclopropenes (DACPs) generated in situ from enoldiazo compounds react with nucleophiles to form alpha-substituted succinic acid derivatives in high yields. Initial dirhodium(II) carboxylate catalysis rapidly converts enoldiazo-acetates or -acetamides to DACPs that undergo catalyst-free Favorskii ring opening with amines, and also with anilines, alcohols, and thiols, when facilitated by catalytic amounts of 4-dimethylaminopyridine (DMAP). This methodology provides easy access to mixed esters and amides of monosubstituted succinic acids, including derivatives of naturally occurring compounds. It also affords dihydrazide, dihydroxamic acid, and diamide derivatives, as well as alpha-substituted tetrahydropyridazine-3,6-diones in high yields. Attempts to generate optically enriched DACPs were not successful because their populations having the R and S configurations formed with a chiral dirhodium catalyst are quite similar, and the loss of enantiocontrol likely originates from the DACP ring forming step which is reversible with its intermediate metal carbene.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Marichev, KO; Wang, K; Greco, N; Dong, KY; Chen, JZ; Lei, JP; Doyle, MP or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles