With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-72-9,1H-Indole,as a common compound, the synthetic route is as follows.
Dimethylsulfoxide (2 mL) was added to a 25 mL pressure-resistant reaction tube, indole (35.1 mg, 0.3 mmol), ethyl trifluoropyruvate(102.0 mg, 0.6 mmol), Cuprous chloride (44.78 mg, 1.5 eq.), The reaction was magnetically stirred in an 80 C oil bath for 12 hours. After the reaction was completed, most of the solvent was distilled off under reduced pressure, and the remaining mixture was purified by column chromatography on petroleum ether / ethyl acetate (10: 1) as eluent to obtain the desired product, As a pale yellow solid, 35.8 mg, yield 56%, 120-72-9
The synthetic route of 120-72-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Lishui College; Yan Guobing; Huang Dayun; He Ping; Cao Xihan; Zheng Wanbin; Ke Qiumin; Shen Xuqian; (5 pag.)CN106946758; (2017); A;,
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