An article Stereoselective Synthesis of Ribofuranoid exo-Glycals by One-Pot Julia Olefination Using Ribofuranosyl Sulfones WOS:000606840200054 published article about C-GLYCOSYLIDENE DERIVATIVES; RAMBERG-BACKLUND REACTION; PROTECTED SUGAR LACTONES; EFFICIENT SYNTHESIS; ENOL ETHERS; STEREOCONTROLLED SYNTHESIS; DEHYDROQUINATE SYNTHASE; CONVENIENT SYNTHESIS; SUBSTRATE-ANALOGS; FACILE SYNTHESIS in [Mori, Ayumi; Suzuki, Kanna; Ando, Kaori] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, Gifu 5011193, Japan; [Oka, Natsuhisa] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, Ctr Highly Adv Integrat Nano & Life Sci, Gifu 5011193, Japan; [Oka, Natsuhisa] Gifu Univ, Inst Glycocore Res iGCORE, Tokai Natl Higher Educ & Res Syst Furo Cho, Gifu 5011193, Japan in 2021, Cited 132. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2
One-pot Julia olefination using ribofuranosyl sulfones is described. The alpha-anomers of the ribofuranosyl sulfones were synthesized with complete alpha-selectivity via the glycosylation of heteroarylthiols using ribofuranosyl iodides as glycosyl donors and the subsequent oxidation of the resulting heteroaryl 1-thioribofuranosides with magnesium monoperphthalate (MMPP). The Julia olefination of the alpha-ribofuranosyl sulfones with aldehydes proceeded smoothly in one pot to afford the thermodynamically less stable (E)-exo-glycals with modest-to-excellent stereoselectivity (up to E/Z = 94:6) under the optimized conditions. The E selectivity was especially high for aromatic aldehydes. In contrast, the (Z)-exo-glycal was obtained as the main product with low stereoselectivity when the corresponding beta-ribofuranosyl sulfone was used (E/Z = 41:59). The remarkable impact of the anomeric configuration of the ribofuranosyl sulfones on the stereoselectivity of the Julia olefination has been rationalized using density functional theory (DFT) calculations. The protected ribose moiety of the resulting exo-glycals induced completely a-selective cyclopropanation on the exocyclic carbon-carbon double bond via the Simmons-Smith-Furukawa reaction. The 2-cyanoethyl group was found to be useful for the protection of the exo-glycals, as it could be removed without affecting the exocyclic C=C bond.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Oka, N; Mori, A; Suzuki, K; Ando, K or concate me.. Computed Properties of C8H8O2
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles