Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about NITRIC-OXIDE SYNTHASE; 2-BENZOYL-6-BENZYLIDENECYCLOHEXANONE ANALOGS; CURCUMIN; INHIBITION; GENERATION; DESIGN; SERIES, Saw an article supported by the Ministry of Higher Education (MOHE) of Malaysia [FRGS/1/2014/ST01/UPM/02/1 (5538011)]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Leong, SW; Awin, T; Faudzi, SMM; Maulidiani, M; Shaari, K; Abas, F. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde
A series of seven new (1, 3, 6, 7, 10, 12, and 13) and six (2, 4, 5, 8, 9, and 11) known diarylpentanoid analogs were synthesized and assessed for their nitric oxide (NO) and alpha-glucosidase inhibitory activities as well as their antioxidant capacity. Nine compounds (2, 3, 4, 5, 6, 8, 11, 12, and 13) were found to exhibit comparable activity to that of curcumin (IC50 = 13.0 mu M), in which compound 8 has displayed strongest NO inhibitory activity with the IC50 values of 17.5 mu M. Meanwhile, four compounds (1, 7, 12, and 13) were found to possess better alpha-glucosidase inhibitory activity than that of curcumin (30.9 mu M), with the IC50 values ranging from 19.4 to 24.9 mu M. On the other hand, none of the synthesized compounds has achieved better DPPH scavenging activities than that of curcumin, indicating the relatively poor antioxidant potential of desired diarylpentanoid structure. Structure-activity relationship (SAR) study disclosed that the existence of meta-hydroxyphenyl and bromo groups is crucial for antiinflammatory and anti-alpha-glucosidase activities, respectively. Molecular docking study showed that bromo moiety could form additional hydrophobic contacts with alpha-glucosidase, thereby increased the inhibition of diarylpentanoid against alpha-glucosidase. The overall results suggested that diarylpentanoids with poly-meta-hydroxylated phenyl ring and multiple bromo groups may lead to the discovery of new diarylpentanoids with both antiinflammatory and anti-alpha-glucosidase activities.
Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Leong, SW; Awin, T; Faudzi, SMM; Maulidiani, M; Shaari, K; Abas, F or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles