Name: Benzyl Alcohol. Recently I am researching about BIOLOGICAL EVALUATION; INHIBITORS; NUCLEOTIDE; ISOFLAVONES; ANALOGS; T-705, Saw an article supported by the National Science Foundation for Young Scientists of China [21502209]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2016T90395]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Guo, S; Xu, MS; Guo, Q; Zhu, FQ; Jiang, XR; Xie, YC; Shen, JS. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a-8c with similar EC50 values (0.20-0.22 mu M) comparative to that of sofosbuvir (EC50= 0.18 mu M) in a genotype 1b based replicon Huh7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC50= 7.3 mu M) and S-29b (EC50= 19.5 mu M). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.
Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Guo, S; Xu, MS; Guo, Q; Zhu, FQ; Jiang, XR; Xie, YC; Shen, JS or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles