An article Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein WOS:000464767700013 published article about STRUCTURAL-CHARACTERIZATION; PROVIRAL DNA; IDENTIFICATION; INHIBITION; BINDING; RECOGNITION; COMPLEX; TAR in [Mori, Mattia; Lang, Maria Chiara Dasso; Palombi, Nastasja; Friggeri, Laura; Botta, Maurizio] Univ Siena, Dept Excellence 2018 2022, Dept Biotechnol Chem & Pharm, Via Aldo Moro 2, I-53100 Siena, Italy; [Saladini, Francesco; Giannini, Alessia; Zazzi, Maurizio] Univ Siena, Dept Med Biotechnol, Viale Mario Bracci 16, I-53100 Siena, Italy; [Kovalenko, Lesia; Mely, Yves] Univ Strasbourg, CNRS, Fac Pharm, Lab Bioimagerie & Pathol,UMR 7021, 74 Route Rhin, F-67401 Illkirch Graffenstaden, France; [De Forni, Davide; Poddesu, Barbara] ViroStat Srl, Viale Umberto I 46, I-07100 Sassari, Italy; [Malancona, Savina; Summa, Vincenzo] IRBM Sci Pk SpA, Via Pontina Km 30-600, I-00071 Pomezia, RM, Italy; [Botta, Maurizio] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, BioLife Sci Bldg,Suite 333,1900 N 12th St, Philadelphia, PA 19122 USA; [Botta, Maurizio] Lead Discovery Siena Srl, Vittorio Alfieri 31, I-53019 Castelnuovo, Berardenga, Italy in 2019.0, Cited 28.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the molecule is deputed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by molecular dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds 6 and 13 showed no cytotoxicity, thus becoming valuable leads for further investigations.
Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Mori, M; Lang, MCD; Saladini, F; Palombi, N; Kovalenko, L; De Forni, D; Poddesu, B; Friggeri, L; Giannini, A; Malancona, S; Summa, V; Zazzi, M; Mely, Y; Botta, M or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles