Nada, DS; Elkady, DS; Elsayed, GH; Abdel-Rahman, AAH; Elmegeed, GA in [Nada, Doaa S.; Abdel-Rahman, Adel A. -H.] Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm, Egypt; [Elkady, Dina S.; Elsayed, Ghada H.; Elmegeed, Gamal A.] Natl Res Ctr, Hormones Dept, Giza 12622, Egypt published Synthesis and cytotoxic evaluation of novel hybrid estrane heterocycles as chemotherapeutic anti-cancer agents in 2021.0, Cited 16.0. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
New synthesized hybrid steroidal heterocyclic compounds have received a lot of attention in view of their biological activities as anticancer agents. In this study, a novel class of hybrid estrane heterocyclic compounds were synthesized and evaluated by analytical and spectral data which proved the validity of these derivatives. The cytotoxicity of synthesized compounds 2a, 2b, 2c, 3b, 8, 10a, 10b, 13, 14, 16a and 19 against three human cell lines: breast cancer cells (MCF-7), prostate cancer cells (PC3), and liver cancer cells (HepG2) has been tested using MTT assay. Compounds 10a, 10b, 2c, and 14 revealed more inhibitory influence on MCF7, PC3 and HepG2 growth than the reference drug doxorubicin (Dox) after 24 h incubation. Noteworthy, the tested compounds 10a, 10b, 2c, and 14 exhibited the most pronounced effect in this respect. The results were confirmed by morphology study.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nada, DS; Elkady, DS; Elsayed, GH; Abdel-Rahman, AAH; Elmegeed, GA or concate me.. HPLC of Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles