Recently I am researching about SYRIAN CIVIL-WAR; IN-VITRO; CUTANEOUS LEISHMANIASIS; ANTILEISHMANIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; MEDICINAL-PLANTS; NATURAL-PRODUCTS; CHENOPODIUM-AMBROSIOIDES; TRADITIONAL MEDICINE; MAIN COMPONENTS, Saw an article supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT)Consejo Nacional de Ciencia y Tecnologia (CONACyT) [298060]; grant FOFI-UAQ [FCQ-2018-11]; CONACYT, MexicoConsejo Nacional de Ciencia y Tecnologia (CONACyT) [0224747]. Published in MDPI in BASEL ,Authors: Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid. HPLC of Formula: C5H8O2
Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), -ionone (3), caryophyllene oxide (4), -caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 +/- 0.36 M). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.
HPLC of Formula: C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles