SDS of cas: 120-14-9. I found the field of Chemistry very interesting. Saw the article Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents published in 2021.0, Reprint Addresses Shaik, AB (corresponding author), Jawaharlal Nehru Technol Univ, Vignan Pharm Coll, Dept Pharmaceut Chem, Vadlamudi 522213, Andhra Pradesh, India.; Bhandare, RR (corresponding author), Ajman Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, POB 346, Ajman, U Arab Emirates.; Rahman, MM (corresponding author), Univ East London, Sch Hlth Sports & Biosci, Med Res Grp, Stratford Campus,Water Lane, London E15 4LZ, England.; Bhandare, RR (corresponding author), Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.
A series of twenty new chloropyrazine conjugated benzothiazepines (22-41) have been synthesized with 58%-95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, H-1 NMR, C-13 NMR spectroscopy and mass spectrometry. The synthesized compounds (22-41) and their precursor chalcones (2-21) were evaluated for antitubercular and cytotoxic activities. Additionally, compounds 22-41 were also tested for antimicrobial activity. Among the chalcone series (2-21), compounds 7 and 14 showed significant antitubercular activities (MICs 25.51 and 23.89 mu M, respectively), whereas among benzothiazepines (22-41), compounds 27 and 34 displayed significant antimicrobial (MICs 38.02 mu M, 19.01 mu M) and antitubercular (MIC 18.10 mu M) activities. Compounds 7 and 41 displayed cytotoxic activities with IC50 of 46.03 +/- 1 and 35.10 +/- 2 mu M respectively. All the compounds were evaluated for cytotoxic activity on normal human liver cell lines (L02) and found to be relatively less selective towards this cell line. The most active compounds identified through this study could be considered as potential leads for the development of drugs with possible antimicrobial, antitubercular, and cytotoxic activities. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Lokesh, BVS; Shahanaaz, S; Rahman, MM or concate me.. SDS of cas: 120-14-9
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles