I found the field of Chemistry very interesting. Saw the article Synthesis of Nerol Derivatives Containing a 1,2,3-Triazole Moiety and Evaluation of Their Activities against Cancer Cell Lines published in 2019.0. Computed Properties of C7H8O, Reprint Addresses Teixeira, RR (corresponding author), Univ Fed Vicosa, Dept Quim, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order to evaluate their potential for drug development. Most of the evaluated physicochemical parameters seemed to be favorable for drug development. In addition, for a better understanding of the biological activity results, 3D quantitative structure-activity relationship (QSAR) studies were carried out. 3D-QSAR studies indicate that the anticancer activities observed for the cell lines HL60 and Jurkat may occur by a similar mechanism of action and the same was found for the Nalm6 and B16F10 cell lines.
About Benzyl Alcohol, If you have any questions, you can contact Teixeira, RR; da Silva, AM; Siqueira, RP; Goncalves, VHS; Pereira, HS; Ferreira, RS; Costa, AV; de Melo, EB; Paula, FR; Ferreira, MMC; Bressan, GC or concate me.. Computed Properties of C7H8O
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles