Application In Synthesis of Benzyl Alcohol. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model published in 2019.0, Reprint Addresses Ahn, JH (corresponding author), Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea.; Choi, SY (corresponding author), Chonnam Natl Univ, Dept Biomed Sci, Med Sch, Gwangju, South Korea.; Shin, MG (corresponding author), Chonnam Natl Univ, Dept Lab Med, Med Sch, Gwangju, South Korea.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.
A new series of 1,3-diketone, heterocyclic and alpha, beta-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Jeong, J; Kim, KH; Kim, DY; Chandrasekaran, G; Kim, M; Pagire, SH; Dighe, M; Choi, EY; Bak, SM; Kim, EY; Shin, MG; Choi, SY; Ahn, JH or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles