An article A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles WOS:000476610900044 published article about DRUG DISCOVERY; TEMPLATED SYNTHESIS; SELECTION; BINDING; PERMEABILITY; SOLUBILITY; DISPLAY; DESIGN in [Stress, Cedric J.; Sauter, Basilius; Schneider, Lukas A.; Gillingham, Dennis] Univ Basel, Dept Chem, St Johanns Ring 19, CH-4056 Basel, Switzerland; [Sharpe, Timothy] Univ Basel, Biozentrum, Biophys Facil, Klingelbergstr 50-70, CH-4056 Basel, Switzerland in 2019.0, Cited 48.0. COA of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Here we show a seven-step chemical synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed.
COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Stress, CJ; Sauter, B; Schneider, LA; Sharpe, T; Gillingham, D or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles