Formula: C8H8O2. Recently I am researching about BRONSTED ACID; AROMATIC-SUBSTITUTION; BENZYLATION; ARENES; ETHERS; MILD; ACTIVATION; BENZENE, Saw an article supported by the Natural Sciences and Engineering Research Council (NSERC) of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC); University of AlbertaUniversity of Alberta. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ang, HT; Rygus, JPG; Hall, DG. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
A general and efficient boronic acid catalyzed Friedel-Crafts alkylation of arenes with benzylic alcohols was previously developed for the construction of unsymmetrical diarylmethane products (X. Mo, J. Yakiwchuk, J. Dansereau, J. A. McCubbin and D. G. Hall, J. Am. Chem. Soc., 2015, 137, 9694). Highly electron-deficient benzylic alcohols, however, were ineffective coupling partners due to the increased difficulty of C-O bond ionization. Herein, we report the use of perfluoropinacol as an effective co-catalyst to improve the reactivity of a boronic acid catalyst in the Friedel-Crafts benzylations of electronically deactivated primary and secondary benzylic alcohols. According to spectroscopic studies, it is believed that perfluoropinacol condenses with the arylboronic acid catalyst to form a highly electrophilic and Lewis acidic boronic ester. This in situ formed species enables a more facile ionization of the benzylic alcohols likely through a mode of activation promoted by a Lewis acid assisted hydronium Bronsted acid generated from the interactions of the transient boronic ester with hexafluoroisopropanol solvent and water.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ang, HT; Rygus, JPG; Hall, DG or concate me.. Formula: C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles