COA of Formula: C7H8O2. Recently I am researching about ESTERIFICATION; ACTIVATION; CLEAVAGE; CONVERSION, Saw an article supported by the National Key R&D Program of China [2016YFA0202902]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572036, 21871059, 21861132002]; Department of Chemistry at Fudan University. Published in SCIENCE PRESS in BEIJING ,Authors: Huang, CY; Li, JP; Wang, JQ; Zheng, QS; Li, ZH; Tu, T. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol
The amide C-N cleavage has drawn a broad interest in synthetic chemistry, biological process and pharmaceutical industry. Transition-metal, luxury ligand or excess base were always vital to the transformation. Here, we developed a transition-metal-free hydrogen-bond-assisted esterification of amides with only catalytic amount of base. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, density functional theory (DFT) calculations and kinetic studies. Besides broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry.
COA of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Huang, CY; Li, JP; Wang, JQ; Zheng, QS; Li, ZH; Tu, T or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles