Recently I am researching about DESIGN; ANTIOXIDANT; INHIBITORS; APOPTOSIS, Saw an article supported by the Deanship of Scientific Research at Umm Al-Qura University [17-MED1-03-0007]. Published in ELSEVIER in AMSTERDAM ,Authors: Alqahtani, AM; Bayazeed, AA. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2
Ten new pyridine linked various substituted thiazole hybrids through (hydrazonomethyl) phenoxy-acetamide spacer were synthesized. The synthetic strategy was based on the reaction of the precursor 2-(4-((2-carbamothioylhydrazono)methyl)phenoxy)-N-(pyridin-2-yl)acetamide (3) with various alpha-halogenated carbonyl compounds (namely; phenacyl bromides, ethyl bromoacetate, diethyl bromomalonate and 3-chloropentane-2,4-dione). Moreover, the cytotoxicity properties of the synthesized compounds have been studied against liver carcinoma (HepG2), laryngeal carcinoma (Hep-2), prostate cancer (PC3), breast cancer (MCF-7) and normal fibroblast cells (W138). The pyridine-thiazole compounds 7 and 10 revealed promising anticancer activity against MCF-7 and HepG2 cell lines with IC50 values in the range 5.36-8.76 mu M compared to the activity of 5-fluorouracil. Docking study provided valuable insights for binding sites of the synthesized compounds with Rho-associated protein kinase (ROCK-1). (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Alqahtani, AM; Bayazeed, AA or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles