An article Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D-3 Dopamine Receptor Agonist WOS:000585210700031 published article about IMPULSE CONTROL DISORDERS; D3 RECEPTOR; IN-VIVO; HIGH-AFFINITY; CRYSTAL-STRUCTURE; BIVALENT LIGANDS; MPTP TOXICITY; FORCE-FIELD; POTENT; PRAMIPEXOLE in [Moritz, Amy E.; Free, R. Benjamin; Akano, Emmanuel O.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, Intramural Res Program, NIH, Bethesda, MD 20892 USA; [Weiner, Warren S.; Aube, Jeffrey; Frankowski, Kevin J.] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66047 USA; [Gandhi, Disha; Aube, Jeffrey; Frankowski, Kevin J.] UNC Eshelman Sch Pharm, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA; [Abramyan, Ara; Shi, Lei] NIDA, Computat Chem & Mol Biophys Unit, Mol Targets & Medicat Discovery Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA; [Keck, Thomas M.] Rowan Univ, Coll Sci & Math, Dept Chem & Biochem, Dept Mol & Cellular Biosci, Glassboro, NJ 08028 USA; [Ferrer, Marc; Hu, Xin; Southall, Noel] NIH, NIH Chem Genom Ctr, Div Preclin Innovat, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA; [Steiner, Joseph] NINDS, NeuroTherapeut Dev Unit, Intramural Res Program, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 101.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2
To identify novel D-3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a beta-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and selectivity. The optimized compound, ML417 (20), potently promotes D3R-mediated beta-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders.
About m-Methoxyphenol, If you have any questions, you can contact Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aube, J; Shi, L; Frankowski, KJ; Sibley, DR or concate me.. Computed Properties of C7H8O2
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