I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors published in 2020.0. Quality Control of m-Methoxyphenol, Reprint Addresses Riedl, R (corresponding author), ZHAW Zurich Univ Appl Sci, Ctr Organ & Med Chem, Inst Chem & Biotechnol, Einsiedlerstr 31, CH-8820 Wadenswil, Switzerland.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol
Sentrin-specific proteases (SENPs) are responsible for the maturation of small ubiquitin-like modifiers (SUMOs) and the deconjugation of SUMOs from their substrate proteins. Studies on prostate cancer revealed an overexpression of SENP1, which promotes prostate cancer progression as well as metastasis. Therefore, SENP1 has been identified as a novel drug target against prostate cancer. Herein, we report the discovery and biological evaluation of potent and selective SENP1 inhibitors. A structure-activity relationship (SAR) of the newly identified pyridone scaffold revealed allosteric inhibitors with very attractive in vitro ADMET properties regarding plasma binding and plasma stability for this challenging target. This study also emphasizes the importance of biochemical mode of inhibition studies for de novo designed inhibitors.
About m-Methoxyphenol, If you have any questions, you can contact Lindenmann, U; Brand, M; Gall, F; Frasson, D; Hunziker, L; Kroslakova, I; Sievers, M; Riedl, R or concate me.. Quality Control of m-Methoxyphenol
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles