Recommanded Product: 4′-Hydroxyacetophenone. In 2019.0 ACS OMEGA published article about HYBRID COMPOUNDS; CYTOTOXIC ACTIVITY; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; IMIDAZOLE; ISOLIQUIRITIGENIN; DERIVATIVES; INHIBITION; ANALOGS in [Yang, Jun-Li; Ma, Yong-Hui; Zhang, Yi-Peng; Tian, Hong-Chang; Huang, Yuan-Cheng; Chen, Wen] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; [Yang, Jun-Li; Li, Yan-Hua; Yang, Li-Juan] Yunnan Minzu Univ, Engn Res Ctr Green Preparat Technol Biobased Mat, Sch Chem & Environm, Kunming 650500, Yunnan, Peoples R China; [Li, Yan] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China in 2019.0, Cited 44.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
A series of novel trimethoxyphenyl-derived chalcone-benzimidazolium salts were synthesized. The biological properties of the compounds were screened in vitro against five different human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole or 2-methyl-benzimidazole ring as well as the 2-naphthylmethyl, 4-methylbenzyl, or 2-naphthylacyl substituent at position-3 of the benzimidazole ring was important to the cytotoxic activity. Notably, (E)-5,6-dimethy1-3-(naphth alen-2-ylmethyl)-1-(3-(4-(3-(3,4,5-trime thoxyphenyl) a cryloyl) phenoxy)propyl)-1H-benzo [d] imidazol-3-ium bromide (7f) was more selective to HL-60, MCF-7, and SW-480 cell lines with IC50 values 8.0-, 11.1-, and 5.8-fold lower than DDP. Studies of the antitumor mechanism of action showed that compound 7f could induce cell-cycle G1 phase arrest and apoptosis in SMMC-7721 cells.
Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yang, JL; Ma, YH; Li, YH; Zhang, YP; Tian, HC; Huang, YC; Li, Y; Chen, W; Yang, LJ or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles